|
Department of Anatomy (LMM), School of Medicine,
Institute of Public Health (CYC), Taiwan, ROC. |
|
Most skin lesions heal delay and
even heal efficiently within 1-2 weeks, the healed tissue is neither
aesthetically nor functionally perfect. Therefore, facilitating skin
healing rate and controlling healed skin quality are major aims of drug
treatment for a wound event. Bismuth subgallate (BS) and Borneol (BO)
are the two components of Sulbogin, a new Vaseline-based wound healing
ointment, one for treating skin wounds. Although BO has antibiotic
function, while BS is widely used clinically, neither has been used
specifically for wound healing.The experiment described here aimed to
study the effect of BS and BO on the healing of skin wounds. This study
also compared the effects of BS and BO with Flamazine cream, which is
currently the most popular drug for wound healing in hospitals.
Full-thickness wounds (3 cm x 3 cm x 0.2 cm) were created on the back of
adult male Sprague-Dawley rats. BS, BO, BS+BO, and Flamazine were then
evenly applied to cheesecloth and placed over the lesion areas. The drug
patches were replaced every 2-3 days until the wound areas were
completely covered by epidermis in any kinds of drug treatment. The
combined BS and BO treatment had the best effect on healing by
decreasing lesion area, while increasing granulation tissue formation,
re-epithelialization, eating behavior and reconstitution of skin
appendages. This investigation showed that BS and BO have a synergistic
effect on the skin wound restoration. |
