期刊發表 | 研究報告

Effect of bismuth subgallate on nitric oxide and prostaglandin E2 production by macrophages.

Lin CY, Shen YH, Wu SH, Lin CH, Hwang SM, Tsai YC.

Institute of Biochemistry, School of Life Science, National Yang-Ming University, 155, Li-Nong St., Sec. 2, Peitou, Taipei, Taiwan, ROC.

Bismuth subgallate (BSG) is used widely in clinics, including Vincent's angina, syphilis, and adenotonsillectomy. This study examined the effects of BSG on nitric oxide (NO) and prostaglandin E2 (PGE2) production in activated RAW 264.7 cells. BSG suppressed production of NO and PGE2 in a dose-dependent manner. BSG could increase TGF-beta1 production, which in turn might promote degradation of iNOS mRNA, thus inhibiting NO production. Additionally, BSG inhibited mPGES protein expression and COX-2 activity in activated RAW 264.7 cells. Exogenous addition of SNP reversed the inhibition effect of PGE2 production by BSG. This behavior indicates that PGE2 inhibition by BSG exerts an indirect effect through NO inhibition.